Join us for a TAIMS (Tuesday AIM Seminar) by AIM Associate member and Pilot awardee, Dr. Mark Burge!
News
Obesity promotes the development of insulin resistance and increases the incidence of colitis-associated cancer (CAC), but whether a blunted insulin action specifically in intestinal epithelial cells...
Liver macrophages (LMs) have been proposed to contribute to metabolic disease through secretion of inflammatory cytokines. However, anti-inflammatory drugs lead to only modest improvements in systemic...
One of world's most important autophagy gatherings
Congratulations to the AIM External Advisory Board Member, Beth Levine (beth.levine@utsouthwestern.edu), on successfully renewing her outstanding HHMI-funded research program in the Center for...
"Variants in Autophagy Related Genes and Clinical Characteristics in Melanoma: A Population-Based"
Based on their lobule location, hepatocytes display differential gene expression, including pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin signaling...
Pathogenic Th17 cells play important roles in many autoimmune and inflammatory diseases. Their function depends on T cell receptor (TCR) signaling and cytokines that activate signal transducer and...
New research from Drs. Anne Simonsen and Terje Johansen:
The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and...
"Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAFV600E-melanoma, autophagy is induced...