Chronic non-communicable diseases share the pathomechanism of increased reactive oxygen species (ROS) production by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, known as Nox. The recent discovery that expression of Nox1, a Nox isoform that has been implicated in the pathogenesis of...
Endocrine therapy is an effective option for the treatment of estrogen receptor alpha (ERα)-positive breast cancers. Unfortunately, a large fraction of women relapse with endocrine-resistant tumors. The presence of constitutively active ERα mutants, found in a subset of relapse tumors, is thought to...
The protein p62/Sequestosome 1 (p62) has been described as a selective autophagy receptor and independently as a platform for pro-inflammatory and other intracellular signaling. How these seemingly disparate functional roles of p62 are coordinated has not been resolved. Here, we show that TAK1, a...
Acylglycerol kinase (AGK) -triggered PTEN phosphorylation is a signaling downstream of TCR and is required for the establishment and maintenance of CD8+ T cell metabolic and functional fitness.
BRD4, one of Bromodomain and extra-terminal domain (BET) proteins that bind to acetylated histones and transcription factors (TFs) and control cell-type-specific transcriptional programs, promotes...
Join us as the AIM Center kicks off the Tuesday AIM Seminar series for fall 2019!
Come and join the AIM Center's 2019 mini-symposium on September 6th, 2019, starting at 9:00am!
The AIM Center is proud to welcome Dr. Anne Simonsen, Keynote speaker, laureate, and King Olav V's...
The AIM center executive committee and staff plus the AIM center International Council of Affiliate members (ICAM) provide a summary on the 2nd year activities that took place at the center. https:/...
A natural dietary, microflora-derived metabolite Urolithin A was identified as a mitophagy activator to improve mitochondria function.
Reducing cholesterol in tumor tissue is a new strategy for restoring T cell function to enhance T cell-based immunotherapy.
