Estrogen exerts extensive and diverse effects throughout the body of women. In addition to the classical nuclear estrogen receptors (ERα and ERβ), the G protein-coupled estrogen receptor GPER is an important mediator of estrogen action. Existing ER-targeted therapeutic agents act as GPER agonists...
Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles. Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a β-galactoside-binding cytosolic lectin, unifies and...
Dysregulation of macroautophagy/autophagy is implicated in obesity and insulin resistance. However, it remains poorly defined how autophagy regulates adipocyte development. Using adipose-specific knockout (KO), KO and double-KO mice, we show that inhibiting MTORC1 by RPTOR deficiency led to...
A BioRxiv preprint in the BioRxiv COVID-19 collection: a study from the AIM center indicating that azithromycin and ciprofloxacin have effects similar to chloroquine in human respiratory epithelial...
Drs. Alison Kell and Suresh Kumar have been awarded the first two CoV2 pilot award by the AIM Center. As the world continues to rally against Covid-19, the AIM center hopes to be at the forefront of...
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. Macrophages take up arginine and ornithine from apoptotic cells and convert...
Macrophage mTORC1 senses protein in the diet in vivo and mediates dietary protein-driven atherosclerosis and lesion complexity by regulating mitophagy and mitochondria apoptosis.
Fatty acid binding protein 5 (FABP5) is gatekeeper of mitochondrial integrity that modulates Treg function via a mechanism involving mtDNA release, cGAS-STING-dependent type I IFN signaling and...
Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown. This study suggests...
We have another round of publications from two AIM Center affiliates, both supported by the AIM Center's P20 grant!
First we have "Preclinical efficacy of the GPER-selective agonist G-1 in mouse...
