While heterogeneity is a key feature of cancer, understanding metabolic heterogeneity at the single-cell level remains a challenge. Here we present 13C-SpaceM, a method for spatial single-cell isotope...
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Glucose, the primary cellular energy source, is metabolized through glycolysis initiated by the rate-limiting enzyme hexokinase (HK). In energy-demanding tissues like the brain, HK1 is the dominant...
Our body tends to produce excess FAs to ensure that the FA availability is not limiting. The surplus FAs are actively re-esterified into glycerides, initiating a cycle of breakdown and resynthesis of...
Hypoxic responses such as hypoxia-inducible factor pathways, have been implicated in a variety of physiological and pathological conditions. However, how oxidases make contributions to oxygen sensing...
Augmented CD4+ T cell response in autoimmunity is characterized by extensive metabolic reprogramming. However, the epigenetic molecule that drives the metabolic adaptation of CD4+ T cells remains...
Contrary to their well-known functions in nutrient breakdown, mitochondria are also important biosynthetic hubs and express an evolutionarily conserved mitochondrial fatty acid synthesis (mtFAS)...
Please join the AIM Center for a Mini e-Symposium on January 9, 2024 with special guest speakers from Toronto, Canada and Cambridge, United Kingdom.
Dr. John Brumell, Professor at the...
The AIM Center is in the process of forming a Council of International Rising Stars (COIRS) for junior investigator, comprised of promising junior investigators in the scientific areas of Autophagy...
Reversible acetylation of mitochondrial proteins is a regulatory mechanism central to adaptive metabolic responses. Yet, how such functionally relevant protein acetylation is achieved remains...
The intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the...