Upon TCR stimulation, pyruvate kinase M2 (PKM2) translocates into the nucleus of CD4+ cells, leading to activation of glycolysis and Th17/Th1 polarization. A small-molecule PKM2 activator TEPP-46...
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Metabolic pathway fatty acid oxidation plays a critical role in the regulation of glycolysis and IFNg production in CD8+ T cells. Obesity promotes breast tumorigenesis by inhibiting CD8+ T cell...
Two new publications have recently been published online through Cell. The first is from AIM Center co-director, Dr. Prossnitz, titled, "A Selective Ligand for Estrogen Receptor Proteins Discriminates...
Adenine nucleotide translocator (ANT) complex inhibits the presequence translocase TIM23, leading to stabilization of PINK1 and promotion of mitophagy in response to bioenergetics collapse. ANT...
Under conditions such as hypoxia or starvation, an mTORC1-lipid signalling pathway initiates mitochondrial proteolysis by YME1L, a mitochondrial inner membrane i-AAA protease. The mTORC1–LIPIN1–YME1L...
Presentations by Dr. Diane Lidke and Dr. Michael Mandell
Presentation by Michael Paffett, PhD; Technical Director at UNM Comprehensive Cancer Center
“Topics in Advanced Light Microscopy: Single Molecule Localization Microscopy”
Presentation by Nora Bizzozero, Ph.D. & Dr. Nikolaos Mellios, M.D., Ph.D.
“Role of circRNAs and RBPs in autophagy and metabolism - implications for neuropsychiatric and neurodegenerative diseases”...
Sony ID7000 Spectral Cell Analyzer
Sony’s newest spectral flow cytometer has up to7 lasers and 188 detectors. The ID7000 allows you to expand your panel design options by resolving fluorochromes...
Mechanisms that regulate metabolites and downstream energy generation are key determinants of T cell cytokine production, but the processes underlying the Th17 profile that predicts the metabolic...