Autophagy is an intracellular pathway for degradation that allows for the recycling of cellular components inside lysosomes to sustain tissue homeostasis. Countless effort has been devoted to help...
News
Published:
| FULLTEXT 01.30.2020
AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic sentinel lectins detect membrane damage leading to ubiquitination responses. Absence of Galectin 9 (Gal9)...
Published:
| FULLTEXT 12.01.2019
Published:
| FULLTEXT 02.22.2020
Slowing down translation in either the cytosol or the mitochondria is a conserved longevity mechanism. Here, we found a non-interventional natural correlation of mitochondrial and cytosolic ribosomal proteins (RPs) in mouse population genetics, suggesting a translational balance. Inhibiting...
For COVID-19 and all other infectious diseases, metabolic processes are intimately connected to the mechanisms of disease pathogenesis and the resulting pathology and pathophysiology, as well as the...
Metformin improves CD4+ T cell autophagy and mitochondrial respiration, ameliorating a newly defined inflammaging profile that echoes inflammation in diabetes. Metformin-sensitive defects in immune...
Presentation by: Eric Prossnitz, Phd |
In addition to the International Council of Affiliate Members (ICAM), the AIM Center announces formation of medical specialties-based sections within its newly formed National Council of Affiliate...
(Special Covid-19/TAIMS)
Bryce C. Chackerian, PhD
“Vaccine strategies for SARS-CoV-2”
David S. Peabody, PhD
“Making a SARS-CoV-2 vaccine on an RNA phage-derived platform”
Published:
| FULLTEXT 11.06.2019
The tripartite motif (TRIM) proteins constitute a family of ubiquitin E3 ligases involved in a multitude of cellular processes, including protein homeostasis and autophagy. TRIM32 is characterized by six protein-protein interaction domains termed NHL, various point mutations in which are associated...