The AIM Center of Biomedical Research Excellence concludes its 4th annual Symposium with the Early Investigator Series on January 18, 2022, at 10am MST.
Join us for talks from two...
News
AIM scientists published in Cell that mammalian autophagosomes are formed via fusion of membranes from endosomes and Golgi. This process is inhibited by SARS-CoV-2 in a fierce intracellular...
The AIM Center of Biomedical Research Excellence announces its 4th annual symposium!
Join us for plenary talks from guests around the world on topics such as covid-19, autophagy, inflammation, and...
A brand new 2021 review on autophagy and immunity by Dr. Deretic. According to the author, this took a whole year to write. It's a summary of what we collectively know about autophagy and immunity...
Autophagy is an intracellular pathway for degradation that allows for the recycling of cellular components inside lysosomes to sustain tissue homeostasis. Countless effort has been devoted to help...
Published:
| FULLTEXT 01.30.2020
AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic sentinel lectins detect membrane damage leading to ubiquitination responses. Absence of Galectin 9 (Gal9)...
Published:
| FULLTEXT 12.01.2019
Published:
| FULLTEXT 02.22.2020
Slowing down translation in either the cytosol or the mitochondria is a conserved longevity mechanism. Here, we found a non-interventional natural correlation of mitochondrial and cytosolic ribosomal proteins (RPs) in mouse population genetics, suggesting a translational balance. Inhibiting...
For COVID-19 and all other infectious diseases, metabolic processes are intimately connected to the mechanisms of disease pathogenesis and the resulting pathology and pathophysiology, as well as the...
Metformin improves CD4+ T cell autophagy and mitochondrial respiration, ameliorating a newly defined inflammaging profile that echoes inflammation in diabetes. Metformin-sensitive defects in immune...