Autophagy balances inflammation in innate immunity.
Authors: Deretic V;Levine B
a Autophagy, Inflammation and Metabolism in Disease (AIM) Center of Biomedical Research Excellence , University of New Mexico Health Sciences Center , Albuquerque , NM , USA.,b Department of Molecular Genetics and Microbiology , University of New Mexico Health Sciences Center , Albuquerque , NM , USA.
c Center for Autophagy Research, Department of Internal Medicine , University of Texas Southwestern Medical Center , Dallas , TX , USA.,d Department of Microbiology , University of Texas Southwestern Medical Center , Dallas , TX , USA.,e Howard Hughes Medical Institute , University of Texas Southwestern Medical Center , Dallas , TX , USA.
Abstract
Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.